Following the House vote Tuesday, Senate Republicans were preparing to push back on the bill, with the president ready to veto it.
Efforts to end the 19-day partial government closure fall into deeper disarray over the president's demand for a U.S.-Mexico border wall.
Protesters interrupt the roll call several times before police remove them from the Senate gallery.
The president has labeled demonstrators "rude elevator screamers" and "paid professionals only looking to make senators look bad."
The announcements by Sens. Susan Collins and Joe Manchin are expected to deal a fatal blow to the opposition, but Democrats are still pressing the fight.
The Supreme Court nominee can expect to spend most of the day sparring with Democratic senators over abortion, guns, executive power and other high-profile issues.
The president plans to meet late Tuesday with House Republicans as lawmakers from both parties are up in arms over the administration's policy of family separation.
The National Park Service has deleted every mention of humans’ role in climate change in drafts of a report on risks from rising seas and storm surge.
The president is focusing on senators from Alaska and Kentucky in an effort to save the party's last-ditch effort to repeal "Obamacare."
Critics chastise Ryan Zinke for allegedly targeting Sen. Lisa Murkowski as payback for her refusal to go along with the GOP's health care plan.