Special-K, the Blues-Battler

Researchers have found that the club drug ketamine, an animal anesthetic, works wonders in treating depression in humans—and works in a completely different way than Prozac or Zoloft, opening up an entirely new approach in the treatment of the disease. (via Andrew Sullivan)

Washington Post:

Ketamine, sweet ketamine, answer to our glutamatergic dreams. In the long November night of the soul, in the ever-dark downpour of depression, it turns out that there might be a better umbrella than Prozac and Zoloft and Paxil and their serotonin-loving ilk.

Of course, when it comes to antidepressants, nobody really knows anything, anyway, so why not go with ketamine, a mild hallucinogen known to club freaks as Special K?

Yes, yes, break out the male Wistar rats and the injection needles—researchers at the National Institute of Mental Health announced a study recently in which 18 chronically depressed patients infused with low dosages of ketamine improved within two hours. Seventy-one percent improved within a day, and nearly 30 percent were depression-free by that time. In 24 hours! These were people who had been dealing with depression from three to 47 years. They had failed to respond to just about every drug on the market.

Most of them stayed depression-free for up to a week.
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From erowid.org