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By Lauren B. Davis

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Ear to the Ground

A Long but Drunken Life

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Posted on Nov 2, 2006
Red wine
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A new study found that obese mice given massive doses of a substance found in red wine enjoyed improved health and increased longevity.  Although the results are promising, a human would have to drink between 750 and 1,500 bottles of wine a day to achieve the dose of resveratrol given to the rodents.


New York Times:

Their report, published electronically yesterday in Nature, implies that very large daily doses of resveratrol could offset the unhealthy, high-calorie diet thought to underlie the rising toll of obesity in the United States and elsewhere, if people respond to the drug as mice do.

Resveratrol is found in the skin of grapes and in red wine and is conjectured to be a partial explanation for the French paradox, the puzzling fact that people in France enjoy a high-fat diet yet suffer less heart disease than Americans.

The researchers fed one group of mice a diet in which 60 percent of calories came from fat. The diet started when the mice, all males, were a year old, which is middle-aged in mouse terms. As expected, the mice soon developed signs of impending diabetes, with grossly enlarged livers, and started to die much sooner than mice fed a standard diet.

Another group of mice was fed the identical high-fat diet but with a large daily dose of resveratrol (far larger than a human could get from drinking wine). The resveratrol did not stop them from putting on weight and growing as tubby as the other fat-eating mice. But it averted the high levels of glucose and insulin in the bloodstream, which are warning signs of diabetes, and it kept the mice’s livers at normal size.

Even more striking, the substance sharply extended the mice’s lifetimes. Those fed resveratrol along with the high- fat diet died many months later than the mice on high fat alone, and at the same rate as mice on a standard healthy diet. They had all the pleasures of gluttony but paid none of the price.

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By Weight Loss Help, November 3, 2006 at 11:39 am Link to this comment
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Good point. It still seems that exercise participation and diet moderation and variety is are good guidelines to follow.

If you’re interested in receiving free diet tips and weight loss information please visit <http://www.nulife-weightloss.com>.

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By Gehad Busher, November 2, 2006 at 11:35 pm Link to this comment
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unfortunately if I remember right the last time I drank 750 and 1,500 bottles of wine in one day it caused me some undesired after effects not the least of was a massive hangover, yes now i am sure of it. dont try to drink that much in a single sitting or it will give you a head ache, nothing a few hundred bottles of aspiren wont fix though, peace to all

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By John, November 2, 2006 at 3:06 pm Link to this comment
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a human would have to drink between 750 and 1,500 bottles of wine a day to achieve the dose of resveratrol given to the rodents

and the problem with that is?

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By mezz, November 2, 2006 at 2:40 pm Link to this comment
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as Dean Martin said, ” I feel sorry for people who don’t drink. You wake up in the morning-and that’s as good as you’re gonna feel all day…”

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By J, November 2, 2006 at 12:41 pm Link to this comment
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Should probably point out that France has one of the highest rates of alcoholism in the world.

Not that I’m giving up the red wine…

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By C Quil, November 2, 2006 at 12:41 pm Link to this comment
(Unregistered commenter)

Red wine is lovely stuff, and good for people too.

True, you would have to drink 1500 bottles of the stuff to get the resveratrol level given to the mice, which is a little excessive, I think, as well as kinda expensive. And think of the calories!

But I think paracetamol is more dangerous to your liver than wine is.

Everything in moderation.

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By A, November 2, 2006 at 8:08 am Link to this comment
(Unregistered commenter)

The wording is incorrect in your title—

RED WINE is NOT good for mice, or humans for that matter.

The studies tested a substance called resveratrol, which is an isolated compound.
It is NOT bound in alcohol.

Red wine, and alchohol for that matter, is inherently TOXIC to the human body. 

Be more responsible when relaying science articles.. this is a really bad case of telephone.. with the original research becoming more and more degraded as it passes from the labs, to the NYTimes, to your blog…

Please take note of this, for the greater health of all.

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